The objective of the research study was to assess the possibility of producing honey powders from post-fermentation buckwheat honey solutions containing different amounts of total extract by means of a spray drying method. The purpose was to produce honey powders having the biological properties similar to those of the baseline material. Aqueous solutions of honey were made and fermented. A medium was added to the solutions containing a preset total extract, which, then, underwent a spray drying process. In the honey, post-fermentation solutions, and honey powders determined were: diastase number, HMF content, pH, total acidity, and content of total polyphenols. It was found that the buckwheat honey analyzed was characterized by a good quality. The content of polyphenols was 40.86 mg gallic acid/100 g of honey. The post-fermentation solutions were characterized by a high pH value, the absence of HMF, and almost a doubled amount of the polyphenols compared to honey. There were produced powders, in which the honey ingredients constituted ca. 50 % of dry matter. They were characterized by a high content of polyphenols (36.62-51.30 mg gal. acid/100 g of honey) and a HMF content level as per the Codex Alimentarius standard or slightly exceeding this limit. The powders produced did not lose enzymatic activity (diastase number ca. 5.0).