Some ingredients of spices & herbs can cause allergic reactions, either by themselves or while crossreacting with allergens of other plants. They can trigger an inhalative, food, or contact allergy. In this paper, those allergens are characterized and described, which are responsible for eliciting an IgE-mediated hypersensitivity reaction. Moreover, there are also described the allergens that cause cross-reactivity between spices & herbs and pollen-derived proteins, among other things by pollens of mugwort, birch, and celery.