In our study, we investigated effect of red wine extract on antioxidant and antithrombosis properties in elderly women (age 68 – 75). We investigated 40 women. Twenty women was in placebo group and twenty was supplemented by red wine extract (RWX), 1g per day for two weeks. Antioxidant properties was assessed by total plasma antioxidant status using FRAP method and plasma total polyphenols concentration. We conclude that supplementation of red wine extract has beneficial effect on antithrombosis properties by increased activity of t-PA (tissue plasminogen activator).